Van de Ven Double Halts The Toffees' Run at New Stadium
The Dutch defender emerged as the initial backline player to net two goals in a English top-flight match for Spurs since Jan Vertonghen in March 2013.
At a glance
Micky Van de Ven heads into the net two times in opening period
Everton's Jake O'Brien has equalizer disallowed after video check
Senegalese midfielder nets third in 89th minute
This loss is the Merseyside club's initial at their new ground
Micky van de Ven found the net twice as Spurs extended their unbeaten run in away games in the top division and handed Everton their initial loss at their new home.
Everton were unbeaten in their five previous fixtures at their new ground at the dockside location, having departed their historic home behind after 133 years at the end of the previous campaign.
But Spurs captain the Dutchman pounced twice from set-pieces in the first half to put their strong form at risk, and they were failed to mount a comeback before the midfielder - assisted by former Toffees attacker the Brazilian - headed home a final goal to seal the victory.
Jake O'Brien believed he had levelled the scores five minutes after the defender's first goal, directing a powerful header past Guglielmo Vicario from an Everton corner.
The Portuguese striker, meanwhile, failed to convert a number of chances, while the Italian goalkeeper made a succession of fine saves to ensure the London club went five away games unbeaten in the Premier League.
But the VAR stepped in, instructing Craig Pawson to review the score on the screen and the official ruled that Jack Grealish and Iliman Ndiaye were in offside positions and had impeded with the Spurs keeper.
The win moves the manager's side into third place in the Premier League, five points off north London rivals and leaders Arsenal.
Everton stay 14th and sit half a dozen points clear of the drop zone.
Tottenham analysis: Van de Ven excels in role at each end of pitch
Following a drab weekday display in the Champions League against the French side, where they managed a only two shots on goal, the manager opted for Randal Kolo Muani in attack instead of former Toffees player Richarlison.
The new arrival was unable to influence the game before being substituted for the substitute after an hour on the pitch, but it turns out he proved unnecessary in the final outcome.
Defender Van de Ven transformed into an attacking force to be reckoned with.
Tottenham's first goal came from a well-worked corner routine, with the midfielder heading the ball back across the face of goal for an free the defender to score.
And Ven de Ven - stepping up as skipper in the Argentine's unavailability - notched his next goal in added time as he rose above Jordan Pickford to head home.
The Dutchman was equally impressive in defensive duties, partnering well with Kevin Danso as the duo handled superbly with the 34 crosses thrown their way by the opposition.
Everton analysis: Everton missing striker's instinct
The club's recent stadium had been a happy hunting ground, but it seems the freshness may have faded slightly and fans headed to the gates after the midfielder's third for Tottenham.
The break in Everton's winning streak at home won't be a massive concern for David Moyes, but their striker situation are.
The forward and the other striker - the Toffees' pair of established centre-forwards - had scored only a single goal between them before the weekend's outing.
And they were failed to add to that miserable tally on a wet and gloomy night on in Liverpool.
Beto's form was summed up when he chose to bicycle-kick a golden opportunity from near the goal, even with having room and opportunity to reposition for a more conventional attempt that would have challenged the keeper.
The substitute, too, was unable to influence the game after replacing the starter in the second half.
It wasn't for a shortage of chance. The majority of Everton's offensive moves came through the winger and the forward, who tirelessly whipped dangerous crosses into the Spurs box.
Upcoming fixtures for both teams?
Everton: The team travel to the Stadium of Light in the Premier League on early November at 20:00 GMT.
Tottenham: Spurs go to St James' Park on late October for their next round League Cup match against the Magpies.